作者：李宇轩，李冬，燕荣锟，李鹏，崔晓云，逯金金，刘静，吴旸，林谦，李岩

单位：

1.100078北京市，北京中医药大学东方医院心内科　 2.100700北京市，北京中医药大学东直门医院心内科 通信作者：李岩，E-mail：erzitaba@163.com

Units：

1.Department of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China 2.Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Corresponding author: LI Yan, E-mail: erzitaba@163.com

关键词：

心肌再灌注损伤; 心肌缺血再灌注损伤; 微RNAs; miRNA; 综述;

Keywords：

Myocardial reperfusion injury; Myocardial ischemic reperfusion injury; MicroRNAs; miRNA; Review

CLC：

DOI：

10.12114/j.issn.1008-5971.2022.00.092

Funds：

国家自然科学基金青年科学基金项目（81803906）；国家自然科学基金面上项目（81973622）；首都卫生发展科研专项项目（首发2020-2-4201，首发2020-4-4204）

摘要：

目前我国急性心肌梗死发病率呈上升趋势,心肌缺血再灌注损伤影响急性心肌梗死患者血运重建效果,因此探索减轻心肌缺血再灌注损伤对提高血运重建疗效、改善急性心肌梗死患者预后具有重要意义。本文介绍了心肌缺血再灌注损伤的发病机制及临床表现,分析了miRNA与心肌缺血再灌注损伤患者炎症反应、血小板、血管内皮功能障碍、心肌损伤程度及发生心室重构、心血管事件的关系,认为miRNA具有作为心肌缺血再灌注损伤生物标志物和治疗靶点的潜力,并总结了中医药通过调控miRNA治疗心肌缺血再灌注损伤的相关研究、挑战与前景,同时指出了临床通过miRNA诊治心肌缺血再灌注损伤存在的问题及挑战。

Abstract：

【Abstract】 At present, the incidence of acute myocardial infarction is increasing in China. Myocardial ischemiareperfusion injury affects the effect of revascularization in patients with acute myocardial infarction. Therefore, exploring howto reduce myocardial ischemia reperfusion injury is of great significance to improve the effect of revascularization and improvethe prognosis of patients with acute myocardial infarction. This paper introduces the pathogenesis and clinical manifestationsof myocardial ischemia reperfusion injury, and analyzes the relationship between miRNA and inflammatory response, platelet,vascular endothelial dysfunction, degree of myocardial injury, ventricular remodeling and cardiovascular events in patientswith myocardial ischemia reperfusion injury, considers that miRNA has the potential as a biomarker and therapeutic target ofmyocardial ischemia reperfusion injury, and summarizes the related research, challenges and prospects of traditional Chinesemedicine in the treatment of myocardial ischemia reperfusion injury by regulating miRNA, and points out the problems andchallenges in the clinical diagnosis and treatment of myocardial ischemia reperfusion injury through miRNA.

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